Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P20749
UPID:
BCL3_HUMAN
Alternative names:
Proto-oncogene BCL3
Alternative UPACC:
P20749
Background:
The B-cell lymphoma 3 protein, also known as Proto-oncogene BCL3, plays a pivotal role in the regulation of transcriptional activation of NF-kappa-B target genes. It functions both in the cytoplasm, where it inhibits the nuclear translocation of the NF-kappa-B p50 subunit, and in the nucleus, where it acts as a transcriptional activator promoting the transcription of NF-kappa-B target genes. Additionally, it contributes to the regulation of cell proliferation.
Therapeutic significance:
Understanding the role of B-cell lymphoma 3 protein could open doors to potential therapeutic strategies.