Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P20849
UPID:
CO9A1_HUMAN
Alternative names:
-
Alternative UPACC:
P20849; Q13699; Q13700; Q5TF52; Q6P467; Q96BM8; Q99225; Q9H151; Q9H152; Q9Y6P2; Q9Y6P3
Background:
Collagen alpha-1(IX) chain is a structural component of hyaline cartilage and the vitreous of the eye, playing a crucial role in maintaining the integrity and function of these tissues. This protein's unique composition and localization underscore its importance in skeletal and ocular health.
Therapeutic significance:
Mutations in the gene encoding Collagen alpha-1(IX) chain are linked to Multiple epiphyseal dysplasia 6 and Stickler syndrome 4, conditions marked by skeletal dysplasia and ocular disorders. Understanding the role of Collagen alpha-1(IX) chain could open doors to potential therapeutic strategies for these debilitating diseases.