Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P21333
UPID:
FLNA_HUMAN
Alternative names:
Actin-binding protein 280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin
Alternative UPACC:
P21333; E9KL45; Q5HY53; Q5HY55; Q8NF52
Background:
Filamin-A, also known as Actin-binding protein 280, plays a pivotal role in cell structure and movement by promoting orthogonal branching of actin filaments and anchoring membrane glycoproteins to the actin cytoskeleton. It is essential for cell-cell contacts, blood vessel and heart development, and neuron migration.
Therapeutic significance:
Filamin-A is implicated in a range of diseases, including developmental disorders and skeletal dysplasias like Periventricular nodular heterotopia and Otopalatodigital syndromes. Understanding Filamin-A's functions could lead to novel therapeutic strategies for these conditions.