Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P21583
UPID:
SCF_HUMAN
Alternative names:
Mast cell growth factor; Stem cell factor; c-Kit ligand
Alternative UPACC:
P21583; A0AV09; A8K2Q4; B7ZLM4; Q16487; Q68DZ2; Q7M4N8; Q9UQK7
Background:
Kit ligand, also known as Stem cell factor or c-Kit ligand, plays a pivotal role in cell survival, proliferation, and melanogenesis. It binds to the protein-tyrosine kinase KIT, activating multiple signaling pathways crucial for hematopoiesis, stem cell maintenance, and mast cell function.
Therapeutic significance:
Kit ligand's involvement in diseases such as familial progressive hyperpigmentation, congenital deafness, and Waardenburg syndrome 2F highlights its potential as a target for therapeutic intervention. Understanding its role could lead to novel treatments for these conditions.