Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
The method involves detailed molecular simulations of the receptor in its native membrane environment, with ensemble virtual screening focusing on its conformational mobility. When dealing with dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets on and between the subunits are established to address all possible mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
P22888
UPID:
LSHR_HUMAN
Alternative names:
Luteinizing hormone receptor
Alternative UPACC:
P22888; Q14751; Q15996; Q9UEW9
Background:
The Lutropin-choriogonadotropic hormone receptor, a pivotal protein in human physiology, serves as the receptor for lutropin-choriogonadotropic hormone. This receptor's activity, crucial for reproductive function, is mediated by G proteins that activate adenylate cyclase, as detailed in scientific literature (PubMed:11847099).
Therapeutic significance:
Linked to Familial male precocious puberty and Luteinizing hormone resistance, this receptor's aberrations manifest in significant reproductive disorders. Understanding its role could unveil new therapeutic strategies for these conditions, highlighting its importance in medical research.