Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P23396
UPID:
RS3_HUMAN
Alternative names:
40S ribosomal protein S3
Alternative UPACC:
P23396; B2R7N5; J3KN86; Q498B5; Q8NI95
Background:
Small ribosomal subunit protein uS3, also known as 40S ribosomal protein S3, is integral to the small ribosomal subunit, facilitating protein synthesis within cells. It possesses endonuclease activity, contributing to DNA repair by cleaving damaged DNA. This protein binds to DNA lesions like 8-oxoG, indicative of its role in combating oxidative stress. Additionally, it interacts with various proteins to regulate DNA repair, transcription, and apoptosis, highlighting its multifunctional nature.
Therapeutic significance:
Understanding the role of Small ribosomal subunit protein uS3 could open doors to potential therapeutic strategies. Its involvement in DNA repair, apoptosis, and transcription regulation positions it as a key player in cellular health and disease prevention.