Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P23759
UPID:
PAX7_HUMAN
Alternative names:
HuP1
Alternative UPACC:
P23759; E9PFV9; Q0VA99; Q2PJS5
Background:
Paired box protein Pax-7, also known as HuP1, plays a pivotal role in the regulation of muscle stem cells proliferation. This transcription factor is crucial for myogenesis and muscle regeneration, orchestrating the development and repair of muscle tissue.
Therapeutic significance:
Pax-7 is implicated in Rhabdomyosarcoma 2, a severe muscle tumor, and Congenital myopathy 19, a muscular disorder. Its involvement in these diseases highlights its potential as a target for therapeutic strategies aimed at treating muscle-related conditions.