Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P23942
UPID:
PRPH2_HUMAN
Alternative names:
Retinal degeneration slow protein; Tetraspanin-22
Alternative UPACC:
P23942; Q5TFH5; Q6DK65
Background:
Peripherin-2, also known as Retinal degeneration slow protein and Tetraspanin-22, plays a crucial role in retinal health. It is essential for the morphogenesis of photoreceptor outer segment disks, maintenance of outer segment disk structure, and the development and organization of the photoreceptor inner segment. Its involvement in maintaining retinal outer nuclear layer thickness underscores its significance in visual function.
Therapeutic significance:
Given its pivotal role in retinal diseases such as Retinitis pigmentosa 7, Retinitis punctata albescens, various forms of macular dystrophy, and central areolar choroidal dystrophy, Peripherin-2 represents a promising target for therapeutic intervention. Understanding the role of Peripherin-2 could open doors to potential therapeutic strategies, offering hope for patients suffering from these debilitating conditions.