Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P25786
UPID:
PSA1_HUMAN
Alternative names:
30 kDa prosomal protein; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome component C2; Proteasome nu chain
Alternative UPACC:
P25786; A8K400; Q53YE8; Q9BRV9
Background:
The Proteasome subunit alpha type-1, known by alternative names such as 30 kDa prosomal protein and Proteasome component C2, plays a pivotal role in cellular function. It is a crucial component of the 20S core proteasome complex, responsible for the proteolytic degradation of intracellular proteins. This degradation is essential for maintaining protein homeostasis, removing misfolded or damaged proteins, and regulating protein levels required for cellular functions.
Therapeutic significance:
Understanding the role of Proteasome subunit alpha type-1 could open doors to potential therapeutic strategies. Its involvement in the ATP-dependent degradation of ubiquitinated proteins and ubiquitin-independent protein degradation pathways highlights its importance in cellular health and disease prevention.