Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
The method involves detailed molecular simulations of the receptor in its native membrane environment, with ensemble virtual screening focusing on its conformational mobility. When dealing with dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets on and between the subunits are established to address all possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P28335
UPID:
5HT2C_HUMAN
Alternative names:
5-hydroxytryptamine receptor 1C; Serotonin receptor 2C
Alternative UPACC:
P28335; B1AMW4; Q5VUF8; Q9NP28
Background:
The 5-hydroxytryptamine receptor 2C, also known as the serotonin receptor 2C, plays a pivotal role in neurotransmission and neuromodulation. This G-protein coupled receptor binds to serotonin, as well as various drugs and psychoactive substances, including LSD, initiating a cascade of signaling events. It modulates neuronal activity, influences appetite, stress responses, and regulates corticosterone release through its effect on calcium ion channels and phosphatidylinositol signaling pathways.
Therapeutic significance:
Understanding the role of 5-hydroxytryptamine receptor 2C could open doors to potential therapeutic strategies. Its involvement in regulating appetite, stress responses, and neuronal activity positions it as a key target for addressing disorders related to these functions.