Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P28360
UPID:
MSX1_HUMAN
Alternative names:
Homeobox protein Hox-7; Msh homeobox 1-like protein
Alternative UPACC:
P28360; A0SZU5; A8K3M1; Q96NY4
Background:
Homeobox protein MSX-1, also known as Homeobox protein Hox-7 and Msh homeobox 1-like protein, plays a pivotal role in craniofacial development, odontogenesis, and limb-pattern formation. Its expression in the developing nail bed mesenchyme is crucial for nail plate thickness and integrity.
Therapeutic significance:
MSX-1 is implicated in several congenital conditions, including selective tooth agenesis, ectodermal dysplasia 3, Witkop type, and non-syndromic orofacial cleft 5. Understanding the role of Homeobox protein MSX-1 could open doors to potential therapeutic strategies for these disorders.