Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P29218
UPID:
IMPA1_HUMAN
Alternative names:
D-galactose 1-phosphate phosphatase; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1
Alternative UPACC:
P29218; B2R733; B4DLN3; B7Z6Q4; J3KQT7; Q9UK71
Background:
Inositol monophosphatase 1, also known as Lithium-sensitive myo-inositol monophosphatase A1, plays a pivotal role in the synthesis of phosphatidylinositol and polyphosphoinositides. This enzyme's broad substrate specificity allows it to process various phosphates, crucial for cellular signaling and metabolic processes.
Therapeutic significance:
The enzyme's link to Intellectual developmental disorder, autosomal recessive 59, underscores its biological importance. Understanding the role of Inositol monophosphatase 1 could open doors to potential therapeutic strategies for this and related neurological disorders.