Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P29373
UPID:
RABP2_HUMAN
Alternative names:
Cellular retinoic acid-binding protein II
Alternative UPACC:
P29373; B2R4Z8; D3DVC5; F1T098; Q6ICN6
Background:
Cellular retinoic acid-binding protein 2, also known as Cellular retinoic acid-binding protein II, plays a pivotal role in the intracellular transport of retinoic acid to the nucleus. It precisely regulates the availability of retinoic acid to nuclear retinoic acid receptors, ensuring optimal receptor activation and subsequent gene expression modulation.
Therapeutic significance:
Understanding the role of Cellular retinoic acid-binding protein 2 could open doors to potential therapeutic strategies. Its critical function in retinoic acid signaling pathways highlights its potential as a target for interventions in diseases where retinoic acid metabolism and signaling are disrupted.