Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P29973
UPID:
CNGA1_HUMAN
Alternative names:
Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
Alternative UPACC:
P29973; A8K7K6; J3KPZ2; Q16279; Q16485; Q4W5E3
Background:
The cGMP-gated cation channel alpha-1, known by alternative names such as Cyclic nucleotide-gated cation channel 1 and Rod photoreceptor cGMP-gated channel subunit alpha, plays a pivotal role in the phototransduction pathway. It functions as a subunit of the rod cyclic GMP-gated cation channel, crucial for converting light into electrical signals in rod photoreceptors.
Therapeutic significance:
Retinitis pigmentosa 49, a form of retinal dystrophy, is directly linked to mutations affecting this protein. Understanding the role of cGMP-gated cation channel alpha-1 could open doors to potential therapeutic strategies for this and similar visual impairments.