Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P30530
UPID:
UFO_HUMAN
Alternative names:
AXL oncogene
Alternative UPACC:
P30530; Q8N5L2; Q9UD27
Background:
Tyrosine-protein kinase receptor UFO, also known as AXL oncogene, plays a pivotal role in transmitting signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6. This process regulates cell survival, proliferation, migration, and differentiation. AXL's activation leads to the phosphorylation of various substrates, including PI3-kinase subunits and GRB2, crucial for downstream signaling pathways like AKT kinase activation.
Therapeutic significance:
Understanding the role of Tyrosine-protein kinase receptor UFO could open doors to potential therapeutic strategies. Its involvement in key physiological processes and immune response modulation, particularly through GAS6/AXL signaling, highlights its potential as a target for therapeutic intervention in diseases where these pathways are dysregulated.