Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P30679
UPID:
GNA15_HUMAN
Alternative names:
Epididymis tissue protein Li 17E; Guanine nucleotide-binding protein subunit alpha-16
Alternative UPACC:
P30679; E9KL40; E9KL47; O75247; Q53XK2
Background:
Guanine nucleotide-binding protein subunit alpha-15, also known as Epididymis tissue protein Li 17E and Guanine nucleotide-binding protein subunit alpha-16, plays a pivotal role in transmembrane signaling systems as a modulator or transducer. Its involvement in cellular communication underscores its importance in maintaining cellular homeostasis and responding to external signals.
Therapeutic significance:
Understanding the role of Guanine nucleotide-binding protein subunit alpha-15 could open doors to potential therapeutic strategies. Its central role in signal transduction pathways presents a unique opportunity for targeted drug discovery efforts aimed at modulating its activity for therapeutic benefit.