Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P31483
UPID:
TIA1_HUMAN
Alternative names:
Nucleolysin TIA-1 isoform p40; RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; p40-TIA-1
Alternative UPACC:
P31483; Q53SS9; Q96B58
Background:
The Cytotoxic granule associated RNA binding protein TIA1, also known as Nucleolysin TIA-1 isoform p40, plays a pivotal role in RNA metabolism. It regulates alternative pre-RNA splicing and mRNA translation by binding to uridine-rich sequences. Its involvement in modulating splicing of apoptotic genes and stress-induced translational arrest highlights its significance in cellular stress response and apoptosis.
Therapeutic significance:
TIA1's association with diseases such as Welander distal myopathy and Amyotrophic lateral sclerosis 26 underscores its therapeutic potential. Understanding the role of TIA1 could open doors to potential therapeutic strategies for these neurodegenerative disorders, offering hope for targeted interventions.