Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P31943
UPID:
HNRH1_HUMAN
Alternative names:
-
Alternative UPACC:
P31943; B3KW86; D3DWQ2; Q6IBM4
Background:
Heterogeneous nuclear ribonucleoprotein H plays a pivotal role in the post-transcriptional modification of pre-mRNAs, influencing alternative splicing and the production of functional mRNAs. Its interaction with components like CUGBP1 modulates insulin receptor mRNA splicing, showcasing its regulatory capacity in gene expression.
Therapeutic significance:
The protein's involvement in neurodevelopmental disorder with craniofacial dysmorphism and skeletal defects highlights its potential as a target for therapeutic intervention. Understanding the role of Heterogeneous nuclear ribonucleoprotein H could open doors to potential therapeutic strategies.