Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P32320
UPID:
CDD_HUMAN
Alternative names:
Cytidine aminohydrolase
Alternative UPACC:
P32320
Background:
Cytidine deaminase, also known as cytidine aminohydrolase, plays a crucial role in nucleotide metabolism by scavenging exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. This enzyme's activity is pivotal for maintaining the balance of nucleotide pools within the cell, ensuring proper DNA and RNA synthesis.
Therapeutic significance:
Understanding the role of Cytidine deaminase could open doors to potential therapeutic strategies. Its critical function in nucleotide metabolism highlights its potential as a target for developing treatments for metabolic disorders or diseases related to nucleotide imbalance.