Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P34130
UPID:
NTF4_HUMAN
Alternative names:
Neurotrophin-5; Neutrophic factor 4
Alternative UPACC:
P34130; Q6FH56
Background:
Neurotrophin-4, also known as Neurotrophin-5 and Neutrophic factor 4, plays a pivotal role as a target-derived survival factor for peripheral sensory sympathetic neurons. Its unique function underscores its importance in the nervous system's development and maintenance.
Therapeutic significance:
Given its association with Glaucoma 1, open angle, O, a condition characterized by optic nerve damage and visual field defects, Neurotrophin-4 presents a promising target for therapeutic intervention. Understanding the role of Neurotrophin-4 could open doors to potential therapeutic strategies.