Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P34897
UPID:
GLYM_HUMAN
Alternative names:
Glycine hydroxymethyltransferase; Serine methylase
Alternative UPACC:
P34897; B7Z9F1; E7EQ19; E7EU43; O00740; Q8N1A5
Background:
Serine hydroxymethyltransferase, mitochondrial, also known as Glycine hydroxymethyltransferase or Serine methylase, plays a pivotal role in cellular metabolism. It catalyzes the conversion of serine to glycine, producing 5,10-methylenetetrahydrofolate, crucial for purine biosynthesis and mitochondrial DNA synthesis. This enzyme's activity is fundamental for maintaining the mitochondrial genome's integrity and supporting mitochondrial translation by providing methyl donors for tRNA modifications.
Therapeutic significance:
The protein is implicated in a neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities, highlighting its critical role in human health. Understanding the role of Serine hydroxymethyltransferase could open doors to potential therapeutic strategies for treating this complex disorder, offering hope for patients and families affected by these severe conditions.