Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P34931
UPID:
HS71L_HUMAN
Alternative names:
Heat shock 70 kDa protein 1-Hom
Alternative UPACC:
P34931; A6NNB0; B0UXW8; O75634; Q2HXR3; Q8NE72; Q96QC9; Q9UQM1
Background:
Heat shock 70 kDa protein 1-like (HSP70-1) functions as a molecular chaperone, playing a crucial role in cellular stress responses, protein folding, and degradation processes. It assists in the correct folding of nascent polypeptides, refolding of misfolded proteins, and the assembly or disassembly of protein complexes, facilitated by ATP hydrolysis cycles.
Therapeutic significance:
Understanding the role of Heat shock 70 kDa protein 1-like could open doors to potential therapeutic strategies, especially in diseases where protein misfolding and cellular stress responses are implicated.