Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This includes comprehensive molecular simulations of the receptor in its native membrane environment, paired with ensemble virtual screening that factors in its conformational mobility. In cases involving dimeric or oligomeric receptors, the entire functional complex is modelled, pinpointing potential binding pockets on and between the subunits to capture the full range of mechanisms of action.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P34998
UPID:
CRFR1_HUMAN
Alternative names:
Corticotropin-releasing hormone receptor 1
Alternative UPACC:
P34998; B4DIE9; Q13008; Q4QRJ1; Q9UK64
Background:
Corticotropin-releasing factor receptor 1 (CRFR1) is a pivotal G-protein coupled receptor, binding with high affinity to CRH and UCN. It plays a crucial role in signaling pathways by promoting adenylate cyclase activation, leading to increased cAMP levels, and inhibiting CACNA1H calcium channel activity. Essential for adrenal gland development and stress response, CRFR1's involvement in anxiogenic stimuli response underscores its biological significance.
Therapeutic significance:
Understanding the role of Corticotropin-releasing factor receptor 1 could open doors to potential therapeutic strategies.