Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P35237
UPID:
SPB6_HUMAN
Alternative names:
Cytoplasmic antiproteinase; Peptidase inhibitor 6; Placental thrombin inhibitor
Alternative UPACC:
P35237; B2RBA8; Q59F97; Q5TD06; Q7Z2Y7; Q96J44; Q9UDI7
Background:
Serpin B6, known by its alternative names such as Cytoplasmic antiproteinase, Peptidase inhibitor 6, and Placental thrombin inhibitor, plays a crucial role in the regulation of serine proteinases in the brain and other tissues. It acts as an inhibitor of cathepsin G, kallikrein-8, and thrombin, suggesting its protective role in various physiological processes.
Therapeutic significance:
Serpin B6's involvement in Deafness, autosomal recessive, 91, highlights its critical function in sensorineural hearing loss prevention. This connection underscores the potential of targeting Serpin B6 for therapeutic strategies aimed at mitigating hearing loss.