Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P35244
UPID:
RFA3_HUMAN
Alternative names:
Replication factor A protein 3
Alternative UPACC:
P35244; Q549U6
Background:
Replication protein A 14 kDa subunit (RPA3) is a crucial component of the heterotrimeric replication protein A complex (RPA/RP-A), essential for DNA replication and repair. It binds and stabilizes single-stranded DNA intermediates, recruits and activates various proteins and complexes involved in DNA metabolism, thereby playing a pivotal role in DNA replication and response to DNA damage. RPA3's involvement in nucleotide excision repair, base excision repair, and the recruitment of repair factors RAD51 and RAD52 highlights its significance in maintaining genomic integrity.
Therapeutic significance:
Understanding the role of Replication protein A 14 kDa subunit could open doors to potential therapeutic strategies.