Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P35713
UPID:
SOX18_HUMAN
Alternative names:
-
Alternative UPACC:
P35713; Q0VGA9; Q9NPH8
Background:
Transcription factor SOX-18 plays a pivotal role in embryonic cardiovascular development and lymphangiogenesis, binding to specific DNA sequences to activate gene transcription. It is crucial for the differentiation of lymph vessels and postnatal angiogenesis, with a notable function in hair development.
Therapeutic significance:
SOX-18's involvement in Hypotrichosis-lymphedema-telangiectasia syndrome and its renal defect variant highlights its potential as a therapeutic target. Understanding SOX-18's role could open doors to novel treatments for these conditions.