Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P36269
UPID:
GGT5_HUMAN
Alternative names:
Gamma-glutamyl transpeptidase-related enzyme; Gamma-glutamyltransferase 5; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Leukotriene-C4 hydrolase
Alternative UPACC:
P36269; Q53XM9; Q6GMP0; Q96FC1; Q9UFM5
Background:
Glutathione hydrolase 5 proenzyme, also known as Gamma-glutamyltransferase 5, plays a crucial role in cellular processes by cleaving the gamma-glutamyl peptide bond of glutathione and its conjugates. This enzyme is pivotal in maintaining cellular redox balance and metabolizing leukotrienes, substances involved in inflammatory responses. Its ability to catalyze both hydrolysis and transpeptidation reactions underscores its versatility in biochemical pathways.
Therapeutic significance:
Understanding the role of Glutathione hydrolase 5 proenzyme could open doors to potential therapeutic strategies. Its involvement in cleaving bioactive compounds and regulating immune responses highlights its potential as a target in treating diseases related to oxidative stress and inflammation.