Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P36980
UPID:
FHR2_HUMAN
Alternative names:
DDESK59; H factor-like 3; H factor-like protein 2
Alternative UPACC:
P36980; Q14310; Q5T9T1
Background:
Complement factor H-related protein 2, also known as DDESK59, H factor-like 3, and H factor-like protein 2, plays a crucial role in complement regulation. Its ability to form dimers enhances its affinity for tissue-bound complement fragments, allowing it to effectively compete with CFH, a physiological complement inhibitor. Additionally, this protein's association with lipoproteins suggests a significant role in lipid metabolism.
Therapeutic significance:
Understanding the role of Complement factor H-related protein 2 could open doors to potential therapeutic strategies.