Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P37059
UPID:
DHB2_HUMAN
Alternative names:
20 alpha-hydroxysteroid dehydrogenase; E2DH; Estradiol 17-beta-dehydrogenase 2; Microsomal 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C member 2; Testosterone 17-beta-dehydrogenase
Alternative UPACC:
P37059; B2R7T4
Background:
17-beta-hydroxysteroid dehydrogenase type 2 (17β-HSD2) plays a pivotal role in steroid metabolism, catalyzing the NAD-dependent oxidation of potent 17beta-hydroxysteroids like estradiol, testosterone, and dihydrotestosterone into their less active forms. This enzymatic activity is crucial for regulating the biological potency of these steroids, impacting various physiological processes.
Therapeutic significance:
Understanding the role of 17-beta-hydroxysteroid dehydrogenase type 2 could open doors to potential therapeutic strategies. Its involvement in the metabolism of key sex steroids suggests its potential impact on diseases related to steroid hormone imbalance.