Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P37287
UPID:
PIGA_HUMAN
Alternative names:
GlcNAc-PI synthesis protein; Phosphatidylinositol-glycan biosynthesis class A protein
Alternative UPACC:
P37287; B4E0V2; Q16025; Q16250
Background:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A, also known as GlcNAc-PI synthesis protein, plays a pivotal role in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. These anchors are crucial for attaching proteins to cell membranes, impacting various cellular processes.
Therapeutic significance:
This protein's malfunction is linked to diseases such as Paroxysmal nocturnal hemoglobinuria 1, Multiple congenital anomalies-hypotonia-seizures syndrome 2, and Neurodevelopmental disorder with epilepsy and hemochromatosis. Understanding its function could lead to novel treatments for these conditions.