Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P39086
UPID:
GRIK1_HUMAN
Alternative names:
Excitatory amino acid receptor 3; Glutamate receptor 5
Alternative UPACC:
P39086; Q13001; Q86SU9
Background:
The Glutamate receptor ionotropic, kainate 1, also known as Excitatory amino acid receptor 3 or Glutamate receptor 5, plays a pivotal role in neurotransmission. It acts as an ionotropic glutamate receptor, where L-glutamate serves as an excitatory neurotransmitter in the central nervous system. Upon L-glutamate binding, the receptor undergoes a conformational change, opening the cation channel and converting the chemical signal into an electrical impulse.
Therapeutic significance:
Understanding the role of Glutamate receptor ionotropic, kainate 1 could open doors to potential therapeutic strategies.