Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P39656
UPID:
OST48_HUMAN
Alternative names:
-
Alternative UPACC:
P39656; B2RDQ4; B4DJE3; B4DLI2; O43244; Q5VWA5; Q8NI93; Q9BUI2
Background:
The Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit plays a pivotal role in protein N-glycosylation, a fundamental process for protein folding and stability. It is a crucial component of the oligosaccharyl transferase (OST) complex, facilitating the transfer of glycan chains to nascent proteins, essential for their proper function and localization.
Therapeutic significance:
Linked to Congenital disorder of glycosylation 1R, this protein's dysfunction manifests in a wide array of clinical features, including developmental and immunological deficits. Understanding its role could pave the way for innovative treatments targeting glycosylation disorders.