Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P40227
UPID:
TCPZ_HUMAN
Alternative names:
Acute morphine dependence-related protein 2; CCT-zeta-1; HTR3; Tcp20
Alternative UPACC:
P40227; A6NCD2; Q3KP28; Q75LP4; Q96S46
Background:
The T-complex protein 1 subunit zeta, known by alternative names such as Acute morphine dependence-related protein 2, CCT-zeta-1, HTR3, and Tcp20, plays a crucial role in cellular function. It is a component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists in the folding of proteins upon ATP hydrolysis. This complex is vital for the proper folding of key proteins such as WRAP53/TCAB1, which is essential for telomere maintenance, and is also involved in the folding of actin and tubulin.
Therapeutic significance:
Understanding the role of T-complex protein 1 subunit zeta could open doors to potential therapeutic strategies.