Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It includes extensive molecular simulations of the receptor in its native membrane environment and the ensemble virtual screening accounting for its conformational mobility. In the case of dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets are determined on and between the subunits to cover the whole spectrum of possible mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
P41145
UPID:
OPRK_HUMAN
Alternative names:
-
Alternative UPACC:
P41145; E5RHC9; Q499G4
Background:
The Kappa-type opioid receptor, encoded by the gene with accession number P41145, is a G-protein coupled receptor. It binds endogenous alpha-neoendorphins and dynorphins, showing low affinity for beta-endorphins. It also interacts with synthetic opioids and salvinorin A, a psychoactive compound. Activation of this receptor inhibits adenylate cyclase, modulates ion conductance, and affects neurotransmitter release, playing a crucial role in pain perception, physical activity, salivation, arousal, and neuroendocrine functions.
Therapeutic significance:
Understanding the role of Kappa-type opioid receptor could open doors to potential therapeutic strategies.