Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P41247
UPID:
PLPL4_HUMAN
Alternative names:
Calcium-independent phospholipase A2-eta; Protein GS2
Alternative UPACC:
P41247; A8K1H3; B4E362; Q8WW83
Background:
Patatin-like phospholipase domain-containing protein 4, also known as Calcium-independent phospholipase A2-eta and Protein GS2, is encoded by the gene symbol P41247. It exhibits significant triacylglycerol lipase activity, crucial for transferring fatty acids from triglyceride to retinol, hydrolyzing retinylesters, and generating 1,3-diacylglycerol from triglycerides. This protein also demonstrates acylglycerol transacylase and phospholipase A2 activities, playing a pivotal role in lipid metabolism.
Therapeutic significance:
Understanding the role of Patatin-like phospholipase domain-containing protein 4 could open doors to potential therapeutic strategies.