Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P42566
UPID:
EPS15_HUMAN
Alternative names:
Protein AF-1p
Alternative UPACC:
P42566; B2R8J7; D3DPJ2; Q5SRH4
Background:
Epidermal growth factor receptor substrate 15, also known as Protein AF-1p, plays a crucial role in cell growth regulation and proliferation. It is pivotal in the internalization of ligand-inducible receptors, particularly EGFR, and is essential for the assembly of clathrin-coated pits, facilitating post-Golgi trafficking. Its involvement extends to the maturation of clathrin-coated pits, including their invagination or budding, and it is critical in the endocytosis of integrin beta-1 and transferrin receptor.
Therapeutic significance:
Understanding the role of Epidermal growth factor receptor substrate 15 could open doors to potential therapeutic strategies.