Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P43080
UPID:
GUC1A_HUMAN
Alternative names:
Guanylate cyclase activator 1A
Alternative UPACC:
P43080; B3KWT4; Q7Z6T1; Q9NU14
Background:
Guanylyl cyclase-activating protein 1, also known as Guanylate cyclase activator 1A, plays a pivotal role in the visual system. It regulates retinal guanylyl cyclase, crucial for the recovery of rod photoreceptors after light exposure by modulating calcium ion concentration. This protein is instrumental in the light response and recovery mechanisms of cone photoreceptors.
Therapeutic significance:
Linked to Cone dystrophy 3 and Cone-rod dystrophy 14, Guanylyl cyclase-activating protein 1's involvement in these retinal diseases highlights its therapeutic potential. Understanding its role could open doors to novel strategies for treating these vision impairments.