Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P43358
UPID:
MAGA4_HUMAN
Alternative names:
Cancer/testis antigen 1.4; MAGE-4 antigen; MAGE-41 antigen; MAGE-X2 antigen
Alternative UPACC:
P43358; Q14798
Background:
Melanoma-associated antigen 4 (MAGE-4), also known as Cancer/testis antigen 1.4, plays a crucial role in regulating cell proliferation by inhibiting cell cycle arrest at the G1 phase. It also negatively regulates p53-mediated apoptosis, highlighting its pivotal role in cell cycle control and survival mechanisms.
Therapeutic significance:
Understanding the role of Melanoma-associated antigen 4 could open doors to potential therapeutic strategies. Its involvement in cell cycle regulation and apoptosis provides a unique target for cancer therapy, especially in melanoma and other cancers expressing this antigen.