Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P43487
UPID:
RANG_HUMAN
Alternative names:
Ran-binding protein 1
Alternative UPACC:
P43487; Q53EY3
Background:
Ran-specific GTPase-activating protein, also known as Ran-binding protein 1, is pivotal in RAN-dependent nucleocytoplasmic transport. It plays a crucial role in alleviating TNPO1-dependent inhibition of RAN GTPase activity, mediating the dissociation of RAN from nuclear transport proteins, and inducing conformation changes in the XPO1-RAN complex to release cargo proteins. Furthermore, it is essential for normal mitotic spindle assembly and mitosis progression through its effect on RAN.
Therapeutic significance:
Understanding the role of Ran-specific GTPase-activating protein could open doors to potential therapeutic strategies.