Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P46109
UPID:
CRKL_HUMAN
Alternative names:
-
Alternative UPACC:
P46109; A8KA44; D3DX35
Background:
The Crk-like protein, encoded by the gene with the accession number P46109, plays a pivotal role in cellular processes by potentially mediating the transduction of intracellular signals. This protein's involvement in signal transduction pathways underscores its importance in cellular communication and response mechanisms.
Therapeutic significance:
Understanding the role of Crk-like protein could open doors to potential therapeutic strategies. Its central role in signal transduction pathways suggests that modulating its activity could have therapeutic benefits, although specific diseases associated with this protein have yet to be identified.