Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
The method involves detailed molecular simulations of the receptor in its native membrane environment, with ensemble virtual screening focusing on its conformational mobility. When dealing with dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets on and between the subunits are established to address all possible mechanisms of action.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P47211
UPID:
GALR1_HUMAN
Alternative names:
-
Alternative UPACC:
P47211; Q4VBL7
Background:
Galanin receptor type 1 plays a pivotal role in the human body as a receptor for the hormone galanin. Its activity is mediated through G proteins that notably inhibit adenylate cyclase activity, a critical pathway in cellular signaling. This receptor's involvement in such a fundamental process underscores its importance in physiological functions.
Therapeutic significance:
Understanding the role of Galanin receptor type 1 could open doors to potential therapeutic strategies. Its central role in mediating hormonal signals positions it as a key target for drug discovery efforts aimed at modulating hormonal imbalances and related disorders.