Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P47804
UPID:
RGR_HUMAN
Alternative names:
-
Alternative UPACC:
P47804; A6NKK7; Q96FC5
Background:
The RPE-retinal G protein-coupled receptor, encoded by the gene with accession number P47804, plays a pivotal role in vision. It acts as a receptor for all-trans- and 11-cis-retinal, showing a preference for the former. This protein is instrumental in the isomerization of the chromophore, a process critical for the conversion of light into visual signals.
Therapeutic significance:
Retinitis pigmentosa 44, a form of retinal dystrophy, is directly linked to mutations affecting this receptor. The disease manifests as night vision blindness and progressive loss of the visual field, ultimately leading to central vision loss. Understanding the RPE-retinal G protein-coupled receptor's function could pave the way for innovative treatments targeting the underlying genetic causes of this debilitating condition.