Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P47992
UPID:
XCL1_HUMAN
Alternative names:
ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1
Alternative UPACC:
P47992; Q52MA8
Background:
Lymphotactin, also known by alternative names such as ATAC, C motif chemokine 1, and XC chemokine ligand 1, plays a pivotal role in the immune system. It exhibits chemotactic activity specifically for lymphocytes, aiding in their navigation through the body. In the thymus, Lymphotactin is crucial for the medullary accumulation of thymic dendritic cells and supports the development of regulatory T cells, which are essential for establishing self-tolerance and preventing autoimmune responses.
Therapeutic significance:
Understanding the role of Lymphotactin could open doors to potential therapeutic strategies. Its specific function in mediating immune cell navigation and contributing to immune tolerance highlights its potential as a target in treating autoimmune diseases and enhancing immune regulation.