Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P48664
UPID:
EAA4_HUMAN
Alternative names:
Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6
Alternative UPACC:
P48664; Q8N753
Background:
Excitatory amino acid transporter 4, also known as Sodium-dependent glutamate/aspartate transporter and Solute carrier family 1 member 6, is pivotal in neurotransmission. It facilitates the high-affinity uptake of L-glutamate, L-aspartate, and D-aspartate, coupling amino acid transport with Na+ and K+ ions movement. This protein ensures rapid clearance of glutamate from synapses, crucial for neural signal termination.
Therapeutic significance:
Understanding the role of Excitatory amino acid transporter 4 could open doors to potential therapeutic strategies.