Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This includes comprehensive molecular simulations of the receptor in its native membrane environment, paired with ensemble virtual screening that factors in its conformational mobility. In cases involving dimeric or oligomeric receptors, the entire functional complex is modelled, pinpointing potential binding pockets on and between the subunits to capture the full range of mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
P49146
UPID:
NPY2R_HUMAN
Alternative names:
NPY-Y2 receptor
Alternative UPACC:
P49146; Q13281; Q13457; Q4W5G7; Q6AZZ6; Q9UE67
Background:
The Neuropeptide Y receptor type 2, also known as NPY-Y2 receptor, plays a pivotal role in the regulation of energy balance, neuroendocrine function, and anxiety responses through its interaction with neuropeptide Y and peptide YY. It exhibits a specific affinity hierarchy for various pancreatic polypeptides, indicating its selective binding and activation properties.
Therapeutic significance:
Understanding the role of Neuropeptide Y receptor type 2 could open doors to potential therapeutic strategies. Its involvement in critical physiological processes highlights its potential as a target for addressing disorders related to energy balance and stress responses.