Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P49184
UPID:
DNSL1_HUMAN
Alternative names:
DNase X; Deoxyribonuclease I-like 1; Muscle-specific DNase I-like; XIB
Alternative UPACC:
P49184; D3DWW7; Q5HY41
Background:
Deoxyribonuclease-1-like 1, also known by its alternative names DNase X, Deoxyribonuclease I-like 1, Muscle-specific DNase I-like, and XIB, is a protein encoded by the gene with the accession number P49184. This protein plays a crucial role in the degradation of DNA, a process essential for cellular homeostasis and the maintenance of genomic integrity.
Therapeutic significance:
Understanding the role of Deoxyribonuclease-1-like 1 could open doors to potential therapeutic strategies. Its involvement in DNA degradation pathways highlights its potential as a target for diseases where DNA accumulation or genomic integrity is compromised.