Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P49286
UPID:
MTR1B_HUMAN
Alternative names:
-
Alternative UPACC:
P49286
Background:
The Melatonin receptor type 1B, encoded by the gene symbol P49286, plays a pivotal role in the human body by serving as a high affinity receptor for melatonin. This receptor is instrumental in mediating the reproductive and circadian actions of melatonin, functioning through G proteins that inhibit adenylate cyclase activity.
Therapeutic significance:
Understanding the role of Melatonin receptor type 1B could open doors to potential therapeutic strategies. Its involvement in regulating circadian rhythms and reproductive functions highlights its potential as a target for treating related disorders.