Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P49366
UPID:
DHYS_HUMAN
Alternative names:
-
Alternative UPACC:
P49366; A8K688; M0R1I5; Q13184; Q13276; Q9UDG0
Background:
Deoxyhypusine synthase plays a pivotal role in cellular growth and proliferation through its unique enzymatic function. It catalyzes the first step in the post-translational modification of eIF-5A precursor protein, leading to the formation of hypusine, a rare amino acid essential for eIF-5A's activity.
Therapeutic significance:
The protein's involvement in neurodevelopmental disorder with seizures and speech and walking impairment highlights its potential as a therapeutic target. Understanding the role of Deoxyhypusine synthase could open doors to potential therapeutic strategies for treating such neurodevelopmental disorders.