Focused On-demand Library for T-complex protein 1 subunit gamma

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.

Our high-tech, dedicated method is applied to construct targeted libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.

Several key aspects differentiate our library:

Receptor.AI compiles an all-encompassing dataset on the target protein, including historical experiments, literature data, known ligands, and structural insights, maximising the chances of prioritising the most pertinent compounds.
The platform employs state-of-the-art molecular simulations to identify potential binding sites, ensuring the focused library is primed for discovering allosteric inhibitors and binders of concealed pockets.
Over 50 customisable AI models, thoroughly evaluated in various drug discovery endeavours and research projects, make Receptor.AI both efficient and accurate. This technology is integral to the development of our focused libraries.
In addition to generating focused libraries, Receptor.AI offers a full range of services and solutions for every step of preclinical drug discovery, with a pricing model based on success, thereby reducing risk and promoting joint project success.

partner

Reaxense

upacc

P49368

UPID:

TCPG_HUMAN

Alternative names:

CCT-gamma; hTRiC5

Alternative UPACC:

P49368; A6NE14; Q5SZY1; Q9BR64

Background:

T-complex protein 1 subunit gamma, also known as CCT-gamma and hTRiC5, is a crucial component of the chaperonin-containing T-complex (TRiC). This molecular chaperone complex is instrumental in protein folding upon ATP hydrolysis. It specifically aids in the folding of WRAP53/TCAB1, impacting telomere maintenance, and is implicated in the assembly of the BBSome complex, essential for ciliogenesis and vesicle transport to cilia. Additionally, the TRiC complex is involved in the folding of vital cellular components such as actin and tubulin.

Therapeutic significance:

Understanding the role of T-complex protein 1 subunit gamma could open doors to potential therapeutic strategies, particularly in diseases where protein misfolding is a key factor.