Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P49590
UPID:
SYHM_HUMAN
Alternative names:
Histidine--tRNA ligase-like; Histidyl-tRNA synthetase
Alternative UPACC:
P49590; B4DDY8
Background:
Histidine--tRNA ligase, mitochondrial, also known as Histidyl-tRNA synthetase, plays a crucial role in protein synthesis. It catalyzes the ATP-dependent ligation of histidine to its cognate tRNA, a fundamental process for mitochondrial function and cellular energy production.
Therapeutic significance:
Linked to Perrault syndrome 2, a disorder causing deafness and ovarian dysgenesis, Histidine--tRNA ligase's study is pivotal. Understanding its role could unveil new therapeutic strategies for this syndrome, emphasizing the importance of genetic research in uncovering treatment avenues.